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Last updated on 2021-01-26.

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Darlan Conterno Minussi

I’m a computational and experimental biologist with interest in cancer research.

Currently a PhD candidate leveraging single-cell genomics to understand tumor evolution and mechanisms of metastasis. I am passionate about topics that can help progress cancer research and reduce the disease burden faced by patients. I am also actively looking for ways to promote scientific communication and education.

Education

PhD Candidate, Quantitative Sciences

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences

Houston, TX

2020 - 2016

  • Quantitative Sciences Graduate Program, Bioinformatics track. Graduate Research Assistant
  • Working on single-cell copy number data to understand breast cancer tumor heterogeneity
  • Advisor: Nicholas Navin, PhD

MSc, Cellular and Molecular Biology

Federal University of Rio Grande do Sul, UFRGS

Porto Alegre, RS, Brazil

2015 - 2013

  • Thesis: OncoProSim: A tool for in silico tumor evolution analysis
  • Advisor: Guido Lenz, PhD. Co-Advisor: Manuel Menezes de Oliveira Neto, PhD

BS, Biomedicine (Senior year)

Harvard University/Beth Israel Deaconess Medical Center

Boston, MA

2013

  • Thesis: A20 promotes ubiquitination and degradation of Caspase-8 to protect from TRAIL mediated apoptosis: The need to tailor anti-cancer therapies to the molecular signature of the tumor
  • Advisor: Márcia Rosângela Wink, PhD. Co-Advisors: Cleide Gonçalves da Silva, PhD and Christiane Ferran, PhD

BS, Biomedicine

Federal University of Health Sciences of Porto Alegre, UFCSPA

Porto Alegre, RS, Brazil

2012 - 2009

Positions

Undergraduate Researcher

Federal University of Rio Grande do Sul, UFRGS

Porto Alegre, RS, Brazil

2013 - 2011

  • Investigating the role of NTPDase2 on cellular adhesion.
  • Advisor: Guido Lenz. Co-Advisor: Márcia Rosângela Wink

Undergraduate Researcher

Federal University of Health Sciences of Porto Alegre, UFCSPA

Porto Alegre, RS, Brazil

2011 - 2010

  • Impact of environmental pollution in health
  • Advisor: Claudia Ramos Rhoden, PhD

Publications

Breast Tumors Maintain a Reservoir of Subclonal Diversity During Expansion

Under Revision

N/A

2021

  • Minussi, D. C., Nicholson, M. D., Ye, H., Davis, A., Wang, K., Baker, T., Tarabichi, M. Sei, E. Du, H., Rabanni, M., Peng, C., Hu, M., Bai, S. Lin, Y., Schalck, A., Multani, A., Ma, J., McDonaldo, T. O., Casasent, A., Barrera, A., Chen, H., Lim, B., Arun, B. Meric-Bernstam, F. Van Loo, P., Michor, F. Navine, N.

esiCancer : Evolutionary In Silico Cancer Simulator

Cancer Research

N/A

2019

  • Minussi, D. C., Henz, B., Oliveira, S., Filippi-chiela, E. C., Oliveira, M. M., & Lenz, G.

Analysis of NTPDase2 in the cell membrane using fluorescence recovery after photobleaching (FRAP)

Cytometry Part A

N/A

2018

  • Kipper, F.C., A.S.K. Tamajusuku, D.C. Minussi, J.E. Vargas, A.M.O. Battastini, E. Kaczmarek, S.C. Robson, G. Lenz, and M.R. Wink

Systematic Functional Annotation of Somatic Mutations in Cancer

Cancer Cell

N/A

2018

  • Ng PK, Li J, Jeong KJ, Shao S1, Chen H, Tsang YH, Sengupta S, Wang Z, Bhavana VH, Tran R, Soewito S, Minussi DC, Moreno D, Kong K, Dogruluk T, Lu H, Gao J, Tokheim , Zhou DC, Johnson AM, Zeng J, Ip CKM, Ju Z, Wester M, Yu S, Li Y, Vellano CP, Schultz N, Karchin R, Ding L, Lu Y, Cheung LWT, Chen K, Shaw KR, Meric-Bernstam F, Scott KL, Yi S, Sahni N, Liang H, Mills GB.

Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells

Neuro-Oncology

N/A

2016

  • Ledur PF, Liu C, He H, Harris AR, Minussi DC, Zhou H, Shaffrey ME, Asthagiri A, Lopes MBS, Schiff D, Lu Y, Mandell JW, Lenz G, Zong, H

A20 regulates atherogenic interferon (IFN)-gamma signaling in vascular cells by modulating basal IFNbeta levels

The Journal of biological chemistry

N/A

2014

  • Moll HP, Lee A, Minussi DC, da Silva CG, Csizmadia E, Bhasin M, Ferran C

A20 expressing tumors and anticancer drug resistance.

Advances in experimental medicine and biology

N/A

2014

  • da Silva CG, Minussi DC, Ferran C, Bredel M
  • Book Chapter

A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals

Hepatology

N/A

2013

  • da Silva CG, Studer P, Skroch M, Mahiou J, Minussi DC, Peterson CR, Wilson SW, Patel VI, Ma A, Csizmadia E, Ferran C

Awards

Travel Award

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences

N/A

2018

  • Cold Spring Harbor Asia conference on Frontiers in Single Cell Genomics
  • Quantitative Sciences Program

Fellowship

National Counsel of Technological and Scientific Development, CNPq, Brazil

N/A

2013 - 2012

  • Science Without Border Fellowship

Poster Award

Federal University of Health Sciences of Porto Alegre, UFCSPA

Federal University of Health Sciences of Porto Alegre, UFCSPA

2011

  • Interference of NTPDase2 in cellular adhesion

Teaching

Teaching Assistant

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences

Houston, TX

2019

  • Introduction to Bioinformatics
  • Graduate level class

Lecturer

N/A

Houston, TX

2019

  • ASC Data Visualization Workshop

Teaching Assistant

Federal University of Health Sciences of Porto Alegre, UFCSPA

Porto Alegre, RS, Brazil

2014

  • Molecular Biology, course of Biomedicine
  • Undergraduate level class

Teaching Assistant

Federal University of Rio Grande do Sul, UFRGS

Porto Alegre, RS, Brazil

2011

  • Methods in Biophysics, course of Biomedicine
  • Undergraduate level class

Committees

Student Council

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences

Houston, TX

2018

  • Quantitative Sciences Program
  • Member

Student Council

Federal University of Health Sciences of Porto Alegre, UFCSPA

Porto Alegre, RS, Brazil

2011 - 2010

  • Biomedicine
  • President