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Darlan Conterno Minussi
I’m a computational and experimental biologist with interest in cancer research.
Currently a PhD candidate leveraging single-cell genomics to understand tumor evolution and mechanisms of metastasis. I am passionate about topics that can help progress cancer research and reduce the disease burden faced by patients. I am also actively looking for ways to promote scientific communication and education.
Education
PhD Candidate, Quantitative Sciences
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
Houston, TX
2020 - 2016
- Quantitative Sciences Graduate Program, Bioinformatics track. Graduate Research Assistant
- Working on single-cell copy number data to understand breast cancer tumor heterogeneity
- Advisor: Nicholas Navin, PhD
MSc, Cellular and Molecular Biology
Federal University of Rio Grande do Sul, UFRGS
Porto Alegre, RS, Brazil
2015 - 2013
- Thesis: OncoProSim: A tool for in silico tumor evolution analysis
- Advisor: Guido Lenz, PhD. Co-Advisor: Manuel Menezes de Oliveira Neto, PhD
BS, Biomedicine (Senior year)
Harvard University/Beth Israel Deaconess Medical Center
Boston, MA
2013
- Thesis: A20 promotes ubiquitination and degradation of Caspase-8 to protect from TRAIL mediated apoptosis: The need to tailor anti-cancer therapies to the molecular signature of the tumor
- Advisor: Márcia Rosângela Wink, PhD. Co-Advisors: Cleide Gonçalves da Silva, PhD and Christiane Ferran, PhD
BS, Biomedicine
Federal University of Health Sciences of Porto Alegre, UFCSPA
Porto Alegre, RS, Brazil
2012 - 2009
Positions
Undergraduate Researcher
Federal University of Rio Grande do Sul, UFRGS
Porto Alegre, RS, Brazil
2013 - 2011
- Investigating the role of NTPDase2 on cellular adhesion.
- Advisor: Guido Lenz. Co-Advisor: Márcia Rosângela Wink
Undergraduate Researcher
Federal University of Health Sciences of Porto Alegre, UFCSPA
Porto Alegre, RS, Brazil
2011 - 2010
- Impact of environmental pollution in health
- Advisor: Claudia Ramos Rhoden, PhD
Publications
Breast Tumors Maintain a Reservoir of Subclonal Diversity During Expansion
Under Revision
N/A
2021
- Minussi, D. C., Nicholson, M. D., Ye, H., Davis, A., Wang, K., Baker, T., Tarabichi, M. Sei, E. Du, H., Rabanni, M., Peng, C., Hu, M., Bai, S. Lin, Y., Schalck, A., Multani, A., Ma, J., McDonaldo, T. O., Casasent, A., Barrera, A., Chen, H., Lim, B., Arun, B. Meric-Bernstam, F. Van Loo, P., Michor, F. Navine, N.
esiCancer : Evolutionary In Silico Cancer Simulator
Cancer Research
N/A
2019
- Minussi, D. C., Henz, B., Oliveira, S., Filippi-chiela, E. C., Oliveira, M. M., & Lenz, G.
Analysis of NTPDase2 in the cell membrane using fluorescence recovery after photobleaching (FRAP)
Cytometry Part A
N/A
2018
- Kipper, F.C., A.S.K. Tamajusuku, D.C. Minussi, J.E. Vargas, A.M.O. Battastini, E. Kaczmarek, S.C. Robson, G. Lenz, and M.R. Wink
Systematic Functional Annotation of Somatic Mutations in Cancer
Cancer Cell
N/A
2018
- Ng PK, Li J, Jeong KJ, Shao S1, Chen H, Tsang YH, Sengupta S, Wang Z, Bhavana VH, Tran R, Soewito S, Minussi DC, Moreno D, Kong K, Dogruluk T, Lu H, Gao J, Tokheim , Zhou DC, Johnson AM, Zeng J, Ip CKM, Ju Z, Wester M, Yu S, Li Y, Vellano CP, Schultz N, Karchin R, Ding L, Lu Y, Cheung LWT, Chen K, Shaw KR, Meric-Bernstam F, Scott KL, Yi S, Sahni N, Liang H, Mills GB.
Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells
Neuro-Oncology
N/A
2016
- Ledur PF, Liu C, He H, Harris AR, Minussi DC, Zhou H, Shaffrey ME, Asthagiri A, Lopes MBS, Schiff D, Lu Y, Mandell JW, Lenz G, Zong, H
A20 regulates atherogenic interferon (IFN)-gamma signaling in vascular cells by modulating basal IFNbeta levels
The Journal of biological chemistry
N/A
2014
- Moll HP, Lee A, Minussi DC, da Silva CG, Csizmadia E, Bhasin M, Ferran C
A20 expressing tumors and anticancer drug resistance.
Advances in experimental medicine and biology
N/A
2014
- da Silva CG, Minussi DC, Ferran C, Bredel M
- Book Chapter
A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals
Hepatology
N/A
2013
- da Silva CG, Studer P, Skroch M, Mahiou J, Minussi DC, Peterson CR, Wilson SW, Patel VI, Ma A, Csizmadia E, Ferran C
Awards
Travel Award
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
N/A
2018
- Cold Spring Harbor Asia conference on Frontiers in Single Cell Genomics
- Quantitative Sciences Program
Fellowship
National Counsel of Technological and Scientific Development, CNPq, Brazil
N/A
2013 - 2012
- Science Without Border Fellowship
Poster Award
Federal University of Health Sciences of Porto Alegre, UFCSPA
Federal University of Health Sciences of Porto Alegre, UFCSPA
2011
- Interference of NTPDase2 in cellular adhesion
Teaching
Teaching Assistant
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
Houston, TX
2019
- Introduction to Bioinformatics
- Graduate level class
Lecturer
N/A
Houston, TX
2019
- ASC Data Visualization Workshop
Teaching Assistant
Federal University of Health Sciences of Porto Alegre, UFCSPA
Porto Alegre, RS, Brazil
2014
- Molecular Biology, course of Biomedicine
- Undergraduate level class
Teaching Assistant
Federal University of Rio Grande do Sul, UFRGS
Porto Alegre, RS, Brazil
2011
- Methods in Biophysics, course of Biomedicine
- Undergraduate level class
Committees
Student Council
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
Houston, TX
2018
- Quantitative Sciences Program
- Member
Student Council
Federal University of Health Sciences of Porto Alegre, UFCSPA
Porto Alegre, RS, Brazil
2011 - 2010
- Biomedicine
- President